Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
Year: 2018
Type: review
Abstract: Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Aβ phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease.
Source: Frontiers in Neurology
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: MIRNA CONTRIBUTION TO THE SYSTEMIC IMMUNE RESPONSE AND MONOCYTE RECRUITMENT / FUNCTION IN ALZHEIMER´S DISEASE: A COMPARATIVE STUDY IN ALZHEIMER´S DISEASE PATIENTS AND HEALTHY AGE-MATCHED CONTROLS, Dissecting the role of metabotropic glutamate receptor sorting proteins in autism spectrum disorders, The Neuroimmune System in Alzheimer's Disease, Role of SCARF1 in apoptotic cell clearance and prevention of autoimmunity, Understanding the contribution of miRNAs to neuroinflammation in Alzheimer´s disease, Research Training in Rheumatology at Massachusetts General Hospital
OpenAlex ID: W2808735182