EP-1239: Ph II randomized trial comparing cognitive outcomes of proton vs. photon radiation for glioblastoma
Year: 2018
Type: conference-abstract
Abstract: Purpose or ObjectiveTo validate the Graded Prognostic Assessment (GPA) in a cohort of patients with brain metastasis treated with Stereotactic radiosurgery (SRS). Material and MethodsWe retrospectively reviewed our centre experience treating patients with SRS for brain metastasis between January 2011 and December 2016.We analyzed tumour type, RT dose, whether previous whole brain radiotherapy (WBRT) had been administrated or not, immobilization devices, prognostic factors recognized by the GPA, overall survival (OS), and local progression free survival (LPFS).We used the GPA app to calculate the estimated survival expectancy (ES) for each case.We used Kaplan-Meier to compare the ES with the OS, among all patients and adjusted by tumor type.We used the logrank test to measure whether significant survival differences were present. ResultsSeventy eight patients underwent SRS for brain metastasis.In 7 patients it was no possible to calculate the GPA index because the tumour type was not one of the indexed ones.The most common primary tumours were lung adenocarcinomas (42.3%), followed by gastrointestinal cancers (18.3%) and breast cancers (15.5%).The medium dose was 19.1 Gy (14 Gy-25Gy).An optically-guided frameless system was employed in 59.7% patients and a conventional stereotactic head frame was employed in 40.3%.WBRT was administrated in 55% of patients.Neither the immobilization device nor the WBRT impacted in the OS.With a median follow up of 12.1 months, the median OS was 12.1 months and the median GPA ES was 13 months.The OS at 6, 12 and 24 months were 76.1%, 53.4% and 28.1%, respectively.The GPA ES at 6, 12 and 24 months were 77.4%, 64.5% and 29.2%, respectively.Not significant differences were found neither in the global analyses, nor in the subgroups analyses.The LPFS was 10 months. ConclusionOur results confirm that GPA is a useful tool that accurately predicts the life expectancy of patients with brain metastasis treated with SRS in our environment.SRS achieves good rates of local control in patients with brain metastasis.The administration of WBRT and the employement of frameless devices did not impact on the OS.
Source: Radiotherapy and Oncology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,770
OpenAlex ID: W2808826087