Year: 2018
Type: conference-paper
Abstract: Gene expression profiling provides comprehensive characterization of cellular states under different experimental conditions, thus contributes to the prosperity of many fields of biomedical research. Although the rapid development of gene expression profiling has been observed, genome-wide profiling of large libraries is still expensive and difficult. Due to the fact that there are significant correlations between gene expression patterns, previous studies introduced regression models for predicting the target gene expressions from the landmark gene profiles. These models formulate the gene expression inference in a completely supervised manner, which require a large labeled dataset (i.e. paired landmark and target gene expressions). However, collecting the whole gene expressions is much more expensive than the landmark genes. In order to address this issue and take advantage of cheap unlabeled data (i.e. landmark genes), we propose a novel semi-supervised deep generative model for target gene expression inference. Our model is based on the generative adversarial network (GAN) to approximate the joint distribution of landmark and target genes, and an inference network to learn the conditional distribution of target genes given the landmark genes. We employ the reliable generated data by our GAN model as the extra training pairs to improve the training of our inference model, and utilize the trustworthy predictions of the inference network to enhance the adversarial training of our GAN network. We evaluate our model on the prediction of two types of gene expression data and identify obvious advantage over the counterparts.
Institution: University of Pittsburgh
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: ABI Innovation: A New Automated Data Integration, Annotations, and Interaction Network Inference System for Analyzing Drosophila Gene Expression, G2120299213, III: Medium: Collaborative Research: Robust Large-Scale Electronic Medical Record Data Mining Framework to Conduct Risk Stratification for Personalized Intervention, G5520316217, BIGDATA: Collaborative Research: IA: Big Imaging-Omics Data Mining Framework for Precision Medicine, III: Small: Robust Large-Scale Data Mining for Knowledge Discovery in Depression Thought Records, SCH: EXP: Collaborative Research: Privacy-Preserving Framework for Publishing Electronic Healthcare Records, G9000211028, G9000243647
OpenAlex ID: W2808834459