Year: 2018
Type: review
Abstract: Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a dreadful pathogenic potential to cause a variety of community and hospital-acquired infections. The frequency of these infections is increasing and their treatment is becoming more difficult. The ability of S. aureus to form biofilms and the emergence of multidrug-resistant strains are the main reasons determining the challenge in dealing with these infections. S. aureus' infectious capacity and its success as a pathogen is related to the expression of virulence factors, among which the production of a wide variety of toxins is highlighted. For this reason, a better understanding of S. aureus toxins is needed to enable the development of new strategies to reduce their production and consequently improve therapeutic approaches. This review focuses on understanding the toxin-based pathogenesis of S. aureus and their role on infectious diseases.
Source: Toxins
Authors: Diana Oliveira, Anabela Borges, Manuel Simões
Institution: Universidade do Porto
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,258
Awards: G1516346500, G1763632427, G2470555640, DESIGN AND DEVELOPMENT OF NEW ANTIMICROBIALS FOR BIOFILM CONTROL USING PHYTOCHEMICALS AS SCAFFOLDS, G274581676, G288870757, G2901485428, G2958914557, G3840324753, G3891694003, G419255200, G4316116677, G491858407, G5077953895, G5224927334, LEPABE-2-ECO-INNOVATION, G6277841239, G7584003722, G7965899483, UID/EQU/00511 .: Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia, G96847669
OpenAlex ID: W2808857036