How phenotype guides management of the neuroendocrine carcinomas of the larynx
Year: 2018
Type: review
Abstract: OBJECTIVE: This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx. METHOD: A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusionWhile many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.
Institutions: Universidad de Oviedo, Instituto de Salud Carlos III, Hospital Universitario Central de Asturias, Centro de Investigación Biomédica en Red de Cáncer, University of Arkansas for Medical Sciences, NHS Lothian, University of Udine, The University of Texas MD Anderson Cancer Center, Hospital Clínic de Barcelona, Universitat de Barcelona
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2808861075