Year: 2018
Type: conference-abstract
Abstract: S232 ESTRO 37irradiation, in 1-8 treatment fractions.Its clinical use for treating lung nodules, starting from small peripheral lesions to larger tumors, and lately close to critical structures, progressively increased hand in hand with technology.Many international scientific societies and networks now consider SBRT as the first line non-surgical treatment option for medically inoperable patients affected with stage I NSCLC, and its indications are rapidly expanding also for lung metastases.SBRT has also been used for treating liver, adrenal, bone and lymphnodal metastases, with the potential of combining systemic therapies with a multiple-site low-toxicity local therapy approach for oligometastatic patients.Retrospective and few prospective data are in favor of its use with potential benefit on survival, for example for lung and breast cancer, and a window of opportunity is open for the combination with immunomodulatory agents.Despite major advances and recognized clinical success, high-dose hypo-fractionated SRS-SBRT remains challenging for the whole radiation oncology team, for several reasons (choice of the best dose /fractionation schedule, motion control, planning optimisation, image guidance, etc.).Moreover, a lack of consolidated phase III clinical trials, for both the settings of early stage NSCLC and extra-cranial metastases, is regarded by many oncology specialists as an intrinsic limitation for the wide acceptance of SBRT.The aim of this lecture is to analyze and discuss the results of selected SRS and SBRT studies in light of the technological advances and the clinical needs emerged over the last years, with the aim of placing SRS and SBRT in the context of contemporary oncology and personalized medicine.
Source: Radiotherapy and Oncology
Author: J. Bekelman
Institution: University of Pennsylvania
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,770
OpenAlex ID: W2808920798