Work

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Year: 2018

Type: article

Abstract: Key Points PGN infusion mimics the systemic inflammation and coagulopathy observed in late-stage B anthracis challenge. PGN directly activates the extrinsic coagulation and promotes contact pathway amplification in nonhuman primates.

Source: Blood

DOI: 10.1182/blood-2017-10-813618

Authors: Narcis I. Popescu, Robert Silasi, Ravi S. Keshari, Alanson Girton, Tarea Burgett, Sacha S. Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K. Mark Coggeshall

Institutions: Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Amsterdam UMC Location University of Amsterdam, Sanquin, University of Amsterdam, Vanderbilt University Medical Center, Oregon Health & Science University

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Oklahoma, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Coagulation and Complement Activation in Sepsis, Interdisciplinary Research in Vascular Biology, G5744528203, FXI and Sepsis, G7092830489, Development of a mouse model of peptidoglycan-induced pathology, Molecular and Immunologic Analysis of the Pathobiology of Human Anthrax, Characterization of Coagulation Factor-platelet Interactions: Role of FXI

OpenAlex ID: W2809067157

FWCI: 3.763

Cites: 69

Cited by: 35

Related to: 10