Work

Adapting liposomes for oral drug delivery

Year: 2018

Type: review

Abstract: Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

Source: Acta Pharmaceutica Sinica B

DOI: 10.1016/j.apsb.2018.06.005

Authors: Haisheng He, Yi Lu, Jianping Qi, Quangang Zhu, Zhongjian Chen, Wei Wu

Institutions: Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,600