Work

Transcription infidelity and genome integrity: the parallax view

Year: 2018

Type: editorial

Abstract: It was recently shown that removal of GreA, a transcription fidelity factor, enhances DNA break repair. This counterintuitive result, arising from unresolved backtracked RNA polymerase impeding DNA resection and thereby facilitating RecA-loading, leads to an interesting corollary: error-free full-length transcripts and broken chromosomes. Therefore, transcription fidelity may compromise genomic integrity.

Source: Transcription

DOI: 10.1080/21541264.2018.1491251

Authors: Alasdair J.E. Gordon, Priya Sivaramakrishnan, Jennifer A. Halliday, Christophe Herman

Institutions: Baylor College of Medicine, University of Pennsylvania, Dan L Duncan Comprehensive Cancer Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G306787497, G3945718186, G9000005888, G9000342212

OpenAlex ID: W2809210966

Cites: 34

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Related to: 10