Work

Association between tumor mutation burden (TMB) and MLH1, PMS2, MSH2, and MSH6 alterations in 395 microsatellite instability-high (MSI-High) gastrointestinal (GI) tumors

Year: 2018

Type: article

Study design: Observational Study

Abstract: Introduction: Correlation between TMB and objective response to checkpoint inhibitors has been shown. MSI-High tumors usually exhibit high TMB. Relationship between the level of TMB and alterations in the four-mismatch repair deficiency (MMR) genes in gastrointestinal tumors has not been comprehensively studied.

Source: Annals of Oncology

DOI: 10.1093/annonc/mdy149.024

Authors: M. Salem, A. Grothey, R. Goldberg, J. Xiu, W. Korn, A. Shields, J. Hwang, P. Philip, H. Lenz, J. Marshall

Institutions: Georgetown University, Georgetown Lombardi Comprehensive Cancer Center, Mayo Clinic, The Ohio State University, Caris Life Sciences (United States), The Barbara Ann Karmanos Cancer Institute, USC Norris Comprehensive Cancer Center

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,080

OpenAlex ID: W2809302551

FWCI: 0.485

Cites:

Cited by: 3

Related to: 10