Work

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Year: 2018

Type: article

Abstract: (Cell Reports 15, 1394–1400; May 17, 2016) In the originally published version of this article, the labels “Placebo” and “Metformin” were mistakenly switched in Table S2, which displayed plasma concentrations of amino acids. We have corrected this error as well as the following additional errors, which we would like to bring to the attention of the readers:1.The third bullet point within the Highlights now reads “…metformin increases glucogenic amino acids …” rather than “… metformin decreases glucogenic amino acids …”2.The last sentence of the In Brief blurb now reads “… increased glucagon and glucogenic precursors” rather than “increased glucagon and decreased glucogenic precursors” (the word “decreased” was removed).3.In paragraph 6, line 21 of page 1396, the text now reads “... including decreased metabolites of the urea pathway …” rather than “including elevated metabolites of the urea pathway”4.In paragraph 6, line 26 of page 1396, the text now reads “... revealed an increase in glucogenic AAs” rather than “... revealed a decline in glucogenic AAs” Although amino acid metabolites are not the primary outcome of the work described in this paper and these errors do not alter the main conclusions outlined therein, the authors regret the errors. Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in PrediabetesKonopka et al.Cell ReportsMay 5, 2016In BriefUsing a randomized, double-blinded, placebo-controlled, crossover study design in prediabetic individuals, Konopka et al. show that metformin improves fasting and postprandial glycemia without inhibiting glucagon-stimulated glucose production as reported in preclinical studies. During metformin therapy, increased glucagon and glucogenic precursors may maintain glucose production to prevent hypoglycemia. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2018.05.027