Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5‐Fluorouracil Therapy
Year: 2018
Type: article
Abstract: 5-Fluorouracil (5-FU) is dosed by body surface area, a practice unable to reduce the interindividual variability in exposure. Endorsed by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), we evaluated clinical evidence and strongly recommend TDM for the management of 5-FU therapy in patients with colorectal or head-and-neck cancer receiving common 5-FU regimens. Our systematic methodology provides a framework to evaluate published evidence in support of TDM recommendations in oncology.
DOI: 10.1002/cpt.1124
Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, University of Florida, Keio University, Centre Antoine Lacassagne, Mayo Clinic, Mayo Clinic Comprehensive Cancer Center (Minnesota), Asan Medical Center, University of Ulsan, Erasmus MC, Erasmus MC Cancer Institute, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Asklepios Klinik Altona, Asklepios, Asklepios Kliniken Hamburg, National Cancer Center Hospital, Kantonsspital St. Gallen
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2809457084