Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Year: 2018
Type: article
Source: Nature Medicine
Authors: Yong-Jie Zhang, Tania F. Gendron, Mark T. W. Ebbert, Aliesha D. O’Raw, Mei Yue, Karen Jansen-West, Xu Zhang, Mercedes Prudencio, Jeannie Chew, Casey N. Cook, Lillian M. Daughrity, Jimei Tong, Yuping Song, Sarah R. Pickles, Monica Castanedes-Casey, Aishe Kurti, Rosa Rademakers, Bjorn Oskarsson, Dennis W. Dickson, Wenqian Hu, Aaron D. Gitler, John D. Fryer, Leonard Petrucelli
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Pathophysiology of genetically defined dementia and neurodegeneration: Defining therapeutic targets and pathways, Pathobiology of Neurodegeneration in C9ORF72 repeat expansion, Silencing C9or72 with rAAV Mediated RNAi, Expanding insights into FTD disease mechanisms, Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
OpenAlex ID: W2809559846