Year: 2018
Type: article
Abstract: Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respiratory data from US general population-based cohorts. Data were obtained from prospective cohorts that performed prebronchodilator spirometry and were harmonized following 2005 ATS/ERS standards. In cohorts conducting follow-up for noncardiovascular events, CLRD events were defined as hospitalizations/deaths adjudicated as CLRD-related or assigned relevant administrative codes. Coding and variable names were applied uniformly. The pooled sample included 65,251 adults in 9 cohorts followed-up for CLRD-related mortality over 653,380 person-years during 1983-2016. Average baseline age was 52 years; 56% were female; 49% were never-smokers; and racial/ethnic composition was 44% white, 22% black, 28% Hispanic/Latino, and 5% American Indian. Over 96% had complete data on smoking, clinical CLRD diagnoses, and dyspnea. After excluding invalid spirometry examinations (13%), there were 105,696 valid examinations (median, 2 per participant). Of 29,351 participants followed for CLRD hospitalizations, median follow-up was 14 years; only 5% were lost to follow-up at 10 years. The NHLBI Pooled Cohorts Study provides a harmonization standard applied to a large, US population-based sample that may be used to advance epidemiologic research on CLRD.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwy139
Authors: Elizabeth C Oelsner, Pallavi P Balte, Patricia A Cassano, David Couper, Paul L Enright, Aaron R Folsom, John Hankinson, David R Jacobs, Ravi Kalhan, Robert Kaplan, Richard Kronmal, Leslie Lange, Laura R Loehr, Stephanie J London, Ana Navas Acien, Anne B Newman, George T O’Connor, Joseph E Schwartz, Lewis J Smith, Fawn Yeh, Yiyi Zhang, Andrew E Moran, Stanford Mwasongwe, Wendy B White, Sachin Yende, R Graham Barr
Institutions: Columbia University Irving Medical Center, Columbia University, Weill Cornell Medicine, University of North Carolina at Chapel Hill, University of Arizona, University of Minnesota, Albert Einstein College of Medicine, University of Washington, University of Colorado Denver, National Institutes of Health, National Institute of Environmental Health Sciences, University of Pittsburgh, Boston University, Stony Brook University, University of Oklahoma Health Sciences Center, Jackson State University, Tougaloo College
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,856
Funders: U.S. Department of Health and Human Services, Office of Dietary Supplements, U.S. Environmental Protection Agency, American Thoracic Society, University of Miami, Jackson State University, Northwestern University, San Diego State University, University of Minnesota, School of Medicine, Boston University, University of Washington, University of Pittsburgh, University of Oklahoma, Strong, Stony Brook University, National Institutes of Health, University of Illinois at Urbana-Champaign, Weill Cornell Medical College, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, Graduate School of Public Health, University of Pittsburgh, Feinberg School of Medicine, University of Illinois at Chicago, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities, Mailman School of Public Health, Columbia University
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OpenAlex ID: W2809787362