Work

Synthesis of 8-Hydroxygeraniol

Year: 2018

Type: article

Abstract: An operationally simple protocol for the conversion of geranyl acetate to 8-hydroxygeraniol is reported. The convenient two-step procedure relies on an efficient, chemo- and regioselective SeO 2 -promoted oxidation, followed by straightforward deacetylation. This facile means to prepare 8-hydroxygeraniol is expected to enable biosynthetic studies pertaining to thousands of monoterpene indole alkaloids.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.8b01544

Authors: Francesca M. Ippoliti, Joyann S. Barber, Yi Tang, Neil K. Garg

Institution: University of California, Los Angeles

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources, Division of Chemical, Bioengineering, Environmental, and Transport Systems, Division of Chemistry

Awards: G1515617636, G2495528181, G5627604772, G863947390, G910930967