Current status of immunotherapy against gastrointestinal cancers and its biomarkers: Perspective for precision immunotherapy
Year: 2018
Type: review
Abstract: Immunotherapy has shown encouraging results for some types of tumor. Although enormous efforts have been made toward the development of specific immunotherapeutic strategies against gastrointestinal cancers, such as adoptive T-cell transfer, peptide vaccines, or dendritic cell vaccines, the efficacy of immunotherapies prior to the introduction of immune checkpoint inhibitors was not substantial. This article reviews immunotherapy for gastrointestinal malignancies, including cell therapy, peptide vaccine, and immune checkpoint inhibitors, and attempts to resolve the immunosuppressive conditions surrounding the tumor microenvironment, and to construct novel combination immunotherapies beyond immune checkpoint inhibitors.
DOI: 10.1002/ags3.12180
Institutions: Yamaguchi University, Kawasaki Medical School, Keio University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,350
Awards: Cancer immunology research to enhance therapeutic effects of immune checkpoint blockade, 「効果的な複合免疫療法の確立」(オンコアンチゲン由来ペプチドワクチンにおけるバイオマーカーの検証と治療戦略の構築), G625647337, Investigation of differential immune status among cancer patients and development of personalized cancer therapy by combining immunomodulation, Novel immunotherapy for pancreatic cancer by the multi-HLA binding peptides derived from cancer stemness molecules., Deployment to personalized medicine targeting pancreatic cancer stem cells and tumor microenvironment
OpenAlex ID: W2810128863