MicroRNA miR-223 as regulator of innate immunity
Year: 2018
Type: review
Abstract: MicroRNAs were discovered more than 2 decades ago and have profound impact on diverse biological processes. Specific microRNAs have important roles in modulating the innate immune response and their dysregulation has been demonstrated to contribute to inflammatory diseases. MiR-223 in particular, is very highly expressed and tightly regulated in hematopoietic cells. It functions as key modulator for the differentiation and activation of myeloid cells. The central role of miR-223 in myeloid cells, especially neutrophil and macrophage differentiation and activation has been studied extensively. MiR-223 contributes to myeloid differentiation by enhancing granulopoiesis while inhibiting macrophage differentiation. Uncontrolled myeloid activation has detrimental consequences in inflammatory disease. MiR-223 serves as a negative feedback mechanism controlling excessive innate immune responses in the maintenance of myeloid cell homeostasis. This review summarizes several topics covering the function of miR-223 in myeloid differentiation, neutrophil and macrophage functions, as well as in inflammatory diseases including acute respiratory distress syndrome and inflammatory bowel disease. In addition, nonmyeloid functions of miR-223 are also discussed in this review. Therapeutic enhancement of miR-223 to dampen inflammatory targets is also highlighted as potential treatment to control excessive innate immune responses during mucosal inflammation.
Source: Journal of Leukocyte Biology
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: Amphiregulin Signaling in Perioperative Cardio-Protection, MicroRNA Shuttling during Acute Respiratory Distress Syndrome, Hypoxic Adenosine Responses, Neuronally Active Proteins in IPF, Hypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury, Proton Pump Inhibitors for Perioperative Acute Kidney Injury
OpenAlex ID: W2810698763