Year: 2018
Type: article
Abstract: to cause a regional reduction in myocardial blood flow and inadequate perfusion of the myocardium supplied by the involved coronary artery.For many years, it has been proclaimed that coronary heart disease (CHD) was not applicable to traditional risk factors in up to 50 % of cases and was finally concealed after careful and detailed re-analysis (1).Dyslipidemia is still a major risk factor for CHD.Epidemiological studies have conclusively linked high levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and low levels of high density lipoprotein cholesterol (HDL-C) with CHD incidence and mortality (2).It is well known that early treatment of hyperlipidemia followed by acute myocardial infarction (AMI) provides potential benefits to reduce the morbidity and mortality of CHD.However, lipid and lipoproteins level gets changed during acute illnesses that results delay in treatment choice (3).In post-acute coronary events, acute phasic changes occur that alter the lipid profile levels during tissue necrosis.Modifications of serum lipids after AMI induce the reduction in TC, LDL and HDL, in the range of 10 -20 %, with the reciprocal increase in triglyceride (TG) of approximately 20 -30 % (1).Several mechanisms accounts for these changes which include the acute phase response associated with up-regulation of LDL-receptor (R) activity and reduction in several pivotal HDL regulatory proteins.From many clinical studies it is clear that phasic changes do occur in patients undergone AMI and therefore it is recommended for
Source: Annals of Applied Bio-Sciences
DOI: 10.21276/aabs.1677
Authors: Prashant Kumar, Siddharth Singh, Suresh Prasad, Umesh Prasad Yadav, Pramod Kumar Agrawal
Institution: All India Institute of Medical Sciences, Patna
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2810728136