Work

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Year: 2018

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2018.06.045

Authors: Arun K. Ghosh, Koena Ghosh, Margherita Brindisi, Emma K. Lendy, Yu-Chen Yen, Nagaswamy Kumaragurubaran, Xiangping Huang, Jordan Tang, Andrew D. Mesecar

Institutions: Purdue University West Lafayette, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, University of Oklahoma

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Energy, Purdue University, Purdue University Center for Cancer Research, National Institutes of Health, Office of Science, Office of the Executive Vice President for Research and Partnerships, Purdue University, National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences, Argonne National Laboratory

Awards: G107546177, Cancer Center Support Grant, DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS, Beta Secretase Inhibition for Treating Alzheimer's Disease

OpenAlex ID: W2810957490

FWCI: 0.343

Cites: 23

Cited by: 4

Related to: 10