Work

Improved CNS exposure to tocilizumab after cerebrospinal fluid compared to intravenous administration in rhesus macaques

Year: 2018

Type: article

Abstract: TO THE EDITOR: Neurotoxicity from anti-CD19 chimeric antigen receptor (CAR) T cells, an effective immunotherapy for refractory B-cell malignancies,[1][1][⇓][2][⇓][3][⇓][4][⇓][5]-[6][6] is common and poorly understood. Commonly manifesting as headache, delirium, language disturbances and

Source: Blood

DOI: 10.1182/blood-2018-05-846428

Authors: Anandani Nellan, Cynthia M. Lester McCully, Rafael Cruz Garcia, Nalini Jayaprakash, Brigitte C. Widemann, Daniel W. Lee, Katherine E. Warren

Institutions: Morgan Adams Foundation, Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver, National Institutes of Health, National Cancer Institute, Center for Cancer Research, University of Virginia

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2811098474

FWCI: 4.21

Cites: 20

Cited by: 118

Related to: 10