Aging Alters Circadian Rhythms in the Mouse Eye
Year: 2018
Type: article
Abstract: The eye contains a circadian system that acts independently from the master circadian clock located in the brain. This circadian system regulates important physiological functions within the eye. Emerging experimental evidence also indicates that disruption of the ocular circadian clock, or its outputs, negatively affects the overall health of the eye. Although previous studies have investigated the effect of aging on the regulation of circadian rhythms, no study has investigated the effects of aging on the circadian rhythm in the ocular system. The aim of the present study was to investigate how aging affects the circadian rhythm of PER2::LUC bioluminescence in the retina, retinal pigment epithelium (RPE), and cornea. Our data suggest that among the 3 different ocular tissues investigated, the retina appears to be the most affected by aging whereas the RPE and cornea are less affected by aging. Our data, along with studies of other organs and tissues, suggest that reduction in the amplitude of rhythms is probably the most severe effect of aging on the circadian clock.
Source: Journal of Biological Rhythms
Authors: Kenkichi Baba, Gianluca Tosini
Institution: Morehouse School of Medicine
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Morehouse School of Medicine, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, National Institute on Minority Health and Health Disparities
Awards: Morehouse School of Medicine Center of Excellence Research Endowment Program, Morehouse School of Medicine SNRP, T32 Training Program for Institutions That Promote Diversity from Morehouse School of Medicine, Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center, Retinal Circadian Rhythms and Photoreceptors Viability, Circadian regulation of RPE functions, Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center, RCMI Infrastructure for Clinical and Translational Research (RCTR) (U54), Photic and Circadian Regulation of Retinal Melatonin, RCMI Infrastructure for Clinical and Translational Research (RCTR) (U54)
OpenAlex ID: W2811137840