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Time- and Sex-Dependent Associations Between Prenatal Alcohol Exposure and Placental Global DNA Methylation

Year: 2018
Type: article
Study design: Observational Study
Abstract: AIM: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and placental global DNA methylation. METHODS: Using linear regression analysis, we examined the association between different PAE categories and placental global DNA methylation (n = 187), using the proxy measure of Alu-interspersed repeats. RESULTS: Following adjustment for important covariates, we found no evidence of an association between PAE and placental global DNA methylation overall. However, when stratifying by newborn sex, PAE throughout pregnancy was associated with higher placental global DNA methylation (1.5%; p = 0.01) of male newborns. CONCLUSION: PAE may have sex-specific effects on placental global DNA methylation if alcohol is consumed throughout pregnancy.
Source: Epigenomics
DOI: 10.2217/epi-2017-0147
Authors: Yuk Jing Loke, Evelyne Muggli, Linh Nguyen, Joanne Ryan, Richard Saffery, Elizabeth J Elliott, Jane Halliday, Jeffrey M Craig
Institutions: Royal Children's Hospital, Murdoch Children's Research Institute, The University of Melbourne, Monash University, The University of Sydney, Children's Hospital at Westmead, Sydney Children’s Hospitals Network, Deakin University
Language: English
Open Access status: green
OpenAlex ID: W2811274306
FWCI: 1.659
Cites: 52
Cited by: 47
Related to: 10