Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts
Year: 2018
Type: article
Abstract: Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.
Source: Scientific Reports
Authors: Eloise Berger, Cyrille Delpierre, Fatemeh Saberi Hosnijeh, Michelle Kelly-Irving, Lutzen Portengen, Ingvar A. Bergdahl, Ann-Sofie Johansson, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Soterios A. Kyrtopoulos, Paolo Vineis, Marc Chadeau-Hyam, Roel Vermeulen, Raphaële Castagné, EnviroGenoMarkers, Beatrice Melin, Per Lenner, Benedetta Bendinelli, Maria Botsivali, Aristotelis Chatziioannou, Ioannis Valavanis, Barbara Bodinier, Javiera Garrido-Manriquez, Toby J. Athersuch, Benoît Liquet, Henk Lokhorst, Panagiotis Georgiadis, Jos C. S. Kleinjans, Theo M. C. M. de Kok, Hector C. Keun, Rachel Kelly, Goran Hallmans, Euripides G. Stephanou, Antonis Myridakis, Manolis Kogevinas, Lucia Fazzo, Marco De Santis, Pietro Comba, Hannu Kiviranta, Panu Rantakokko, Riikka Airaksinen, Paivi Ruokojarvi, Mark Gilthorpe, Sarah Fleming, Thomas Fleming, Yu-Kang Tu, Thomas Lundh, Kuo-Liong Chien, Wei J. Chen, Wen-Chung Lee, Chuhsing Kate Hsiao, Po-Hsiu Kuo, Hung Hung, Shu-Fen Liao
Institutions: Université Toulouse III - Paul Sabatier, Inserm, Utrecht University, Erasmus MC, Umeå University, Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto per lo Studio e la Prevenzione Oncologica, Federico II University Hospital, University of Naples Federico II, Piedmont Reference Center for Epidemiology and Cancer Prevention, National Hellenic Research Foundation, Italian institute for Genomic Medicine, MRC Centre for Environment and Health, Imperial College London, Centre National de la Recherche Scientifique, Université de Pau et des Pays de l'Adour, Queensland University of Technology, Laboratoire de Mathématiques et de leurs Applications, ARC Centre of Excellence for Mathematical and Statistical Frontiers, University Medical Center Utrecht, Maastricht University, Hammersmith Hospital, Brigham and Women's Hospital, Harvard University, University of Crete, Center for Research in Environmental Epidemiology, Barcelona Institute for Global Health, Istituto Superiore di Sanità, Finnish Institute for Health and Welfare, University of Leeds, Lund University, National Taiwan University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,477
OpenAlex ID: W2818611452