Work

Mitochondrial ROS metabolism: 10 Years later

Year: 2015

Type: review

Abstract: The role of mitochondria in oxidative stress is well recognized, but many questions are still to be answered. This article is intended to update our comprehensive review in 2005 by highlighting the progress in understanding of mitochondrial reactive oxygen species (ROS) metabolism over the past 10 years. We review the recently identified or re-appraised sources of ROS generation in mitochondria, such as p66(shc) protein, succinate dehydrogenase, and recently discovered properties of the mitochondrial antioxidant system. We also reflect upon some controversies, disputes, and misconceptions that confound the field.

Source: Biochemistry (Moscow)

DOI: 10.1134/s0006297915050028

Authors: A. Y. Andreyev, Y. E. Kushnareva, A. N. Murphy, A. A. Starkov

Institutions: University of California San Diego, La Jolla Institute for Immunology, Cornell University, Weill Cornell Medicine

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke