Work

Redirection of Metabolism in Response to Fatty Acid Kinase in Staphylococcus aureus

Year: 2018

Type: article

Abstract: plays several important roles in the cell. FakA is important for the activation of the SaeRS two-component system and secreted virulence factors like α-hemolysin. However, the contribution of FakA to cellular metabolism has not been explored. Here, we highlight the metabolic consequence of removal of FakA from the cell. The absence of FakA leads to altered acetate metabolism and altered redox balance, as well as a change in intracellular amino acids. Additionally, the use of environmental amino acid sources is affected by FakA. Together, these results demonstrate for the first time that FakA provides a link between the pathways for exogenous fatty acid use, virulence factor regulation, and other metabolic processes.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00345-18

Authors: Zachary DeMars, Jeffrey L. Bose

Institution: University of Kansas Medical Center

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Nebraska Medical Center, National Institute of Allergy and Infectious Diseases