Work

Myelin Plasticity and Nervous System Function

Year: 2018

Type: review

Abstract: Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function. These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity with broad implications for neurological function. In this article, I consider the contributions of myelin to neural circuit function, the dynamic influences of experience on myelin microstructure, and the role that plasticity of myelin may play in cognition.

Source: Annual Review of Neuroscience

DOI: 10.1146/annurev-neuro-080317-061853

Author: Michelle Monje

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

Funders: U.S. Department of Defense, California Institute for Regenerative Medicine

Awards: THE ROLE OF NEURONAL ACTIVITY IN NF1-ASSOCIATED OPTIC PATHWAY GLIOMAGENESIS, G4119534169, White matter neuroregeneration after chemotherapy: stem cell therapy for “chemobrain”