Myocilin from COS-1 cells binds specifically to NIH3T3 cells
Year: 2009
Type: article
Abstract: Myocilin gene is directly linked to the most common form of glaucoma. The gene product is secreted into aqueous humor and is thought to be involved in the regulation of intraocular pressure. Most of the mutant myocilin proteins accumulate in cultured cells and are not secreted. In this study, through staining experiments of various cell lines, we demonstrated that secreted myocilin could bind to a particular cell surface to exert its function. Myocilin secreted by COS-1 cells was able to bind specifically to the surface of NIH3T3 cells. The binding of myocilin was dependent on the cell density. These results suggest that myocilin recognizes a specific cell and exerts its effect upon binding to the cell surface.
Author: M. Minami
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W283762661