Work

Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures

Year: 2019

Type: article

Abstract: The existence of evolutionary conservation in base pairing is strong evidence for functional elements of RNA structure, although available tools for rigorous identification of structural conservation are limited. R-scape is a recently developed program for statistical prediction of pairwise covariation from sequence alignments, but it initially showed limited utility on long RNAs, especially those of eukaryotic origin. Here we show that R-scape can be adapted for a more powerful analysis of structure conservation in long RNA molecules, including mammalian lncRNAs.

Source: Journal of Molecular Biology

DOI: 10.1016/j.jmb.2019.03.012

Authors: Rafael C.A. Tavares, Anna Marie Pyle, Srinivas Somarowthu

Institutions: Yale University, Howard Hughes Medical Institute, Drexel University

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,500