Work

3-Boryl-2,1-borazaronaphthalene: Umpolung Reagents for Diversifying Naphthalene Isosteres

Year: 2018

Type: article

Abstract: A Pd-catalyzed Miyaura borylation of 3-bromo-2,1-borazaronaphthalenes is reported. This method allows the formation of umpolung reagents for subsequent Pd-mediated cross-coupling. Coupling of this nucleophilic partner with a variety of commercially available aryl- and heteroaryl halides allows facile and rapid diversification of these cores.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.8b01197

Authors: Jordan S. Compton, Borna Saeednia, Christopher B. Kelly, Gary A. Molander

Institution: University of Pennsylvania

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Novel Borazines: Syntheses and Elaboration, A Novel Mechanistic Paradigm for Cross-Coupling