Work

Directed migration: Cells navigate by extracellular vesicles

Year: 2018

Type: article

Abstract: Directional cell motility toward a chemical gradient, chemotaxis, is critical during inflammation, embryogenesis, and cancer metastasis. In this issue, Kriebel et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201710170) demonstrate that the key cAMP chemoattractant for Dictyostelium discoideum amoebas is synthesized within and released from extracellular vesicles to promote chemotaxis.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201806018

Authors: Bong Hwan Sung, Alissa M. Weaver

Institutions: Vanderbilt University, Vanderbilt University Medical Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Secreted RNA during CRC progression biogenesis function and clinical markers, Exosome-Filopodia Interactions, Phenotype Heterogeneity and Dynamics in SCLC, Exosome secretion in breast cancer progression