The relationship of maternal glycemia to childhood obesity and metabolic dysfunction‡
Year: 2018
Type: article
Abstract: Objective: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction.Study design: Secondary analysis of follow-up data 5–10 years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24–31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed. Multivariable regression modeling controlling for maternal and neonatal characteristics was employed.Results: A cohort of 236 untreated mild GDM and 480 non-GDM offspring were analyzed. In the combined cohort, significant correlations existed between fasting, 1, 2, and 3 h maternal glucose and subscapular/triceps ratio (all p < .04) and in all OGTT values other than the 2-hour value for homeostatic model assessment-estimated insulin resistance (HOMA-IR) (all p < .04) and sum of skinfold measurements (all p < .03). No correlation was found between OGTT values and childhood BMI Z-score. Multivariable regression modeling showed that OGTT values were associated with only sum of skinfolds and subscapular/triceps ratio and not with childhood BMI Z-score. Hispanic ethnicity and prepregnancy maternal BMI were most consistently related to childhood BMI Z-score and HOMA-IR, and Hispanic ethnicity with fasting glucose.Conclusions: Among women with untreated mild GDM and those without GDM, maternal glycemia is associated with childhood anthropometric measures of obesity but not childhood BMI, fasting glucose, or insulin resistance. Hispanic ethnicity, maternal BMI, and gestational weight gain were consistently related to childhood BMI.
Authors: Mark B. Landon, Lisa Mele, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Alan T. N. Tita, John M. Thorp, Edward K. Chien, George Saade, William Grobman, Sean C. Blackwell, J. Peter VanDorsten, on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
Institutions: The Ohio State University, George Washington University, University of Utah, The University of Texas Southwestern Medical Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Columbia University, Brown University, University of Alabama at Birmingham, University of North Carolina at Chapel Hill, MetroHealth, MetroHealth Medical Center, Case Western Reserve University, The University of Texas Medical Branch at Galveston, Northwestern University, Memorial Hermann, The University of Texas Health Science Center at Houston, Medical University of South Carolina
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1201304535, G124993864, Maternal Fetal Medicine Network: Data Coordinating Cent*, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, G2454580142, NICHD Maternal Fetal Medicine Units Network, NICHD Maternal-Fetal Medicine Units (MFMU) Network, Maternal-Fetal Medicine Units Network, G3226513114, G3409724790, Cooperative Multicenter Maternal Fetal Medicine Units Networks, G4640344014, G4821171242, G6223460132, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site, Maternal Fetal Medicine Network, G715451306, Carolina Population Center, NICHD Materal Fetal Medicine Units Network, Clinical and Translational Science Collaborative of Cleveland, G8675988754, Clinical and Translational Science Collaborative of Cleveland, UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network - Northwestern Study Center, Yale Clinical and Translational Science Award, Case Western Reserve University Center of the NICHD MFMU Network, NICHD maternal fetal medicine units network, Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1)
OpenAlex ID: W2883151932