Work

The small peptide world in long noncoding RNAs

Year: 2018

Type: review

Abstract: Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologies and with the aid of coding transcript classifiers. Further, a considerable number of reports have revealed the existence of stable, functional small peptides (also known as micropeptides), translated from lncRNAs. In this review, we discuss the methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode.

Source: Briefings in Bioinformatics

DOI: 10.1093/bib/bby055

Authors: Seo-Won Choi, Hyun-Woo Kim, Jin-Wu Nam

Institution: Hanyang University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,885

Funders: National Research Foundation, Korea Health Industry Development Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea