Work

Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates

Year: 2018

Type: article

Abstract: The dynamic interactions of an individual matrix metalloproteinase-1 were imaged and monitored in the presence of either triple-helical or non-triple-helical, partially structured collagen-mimic substrates. The enzyme exhibited ten-fold increased catalytic turnover rates with the structurally modified substrate by skipping the triple-helix unwinding step during the catalytic pathway.

Source: Chemical Communications

DOI: 10.1039/c8cc04601h