Work

A systematic study of the determinants of protein abundance memory in cell lineage

Year: 2018

Type: article

Abstract: Proteins are essential players of life activities. Intracellular protein levels directly affect cellular functions and cell fate. Upon cell division, the proteins in the mother cell are inherited by the daughters. However, what factors and by how much they affect this epigenetic inheritance of protein abundance remains unclear. Using both computational and experimental approaches, we systematically investigated this problem. We derived an analytical expression for the dependence of protein inheritance on various factors and showed that it agreed with numerical simulations of protein production and experimental results. Our work provides a framework for quantitative studies of protein inheritance and for the potential application of protein memory manipulation.

Source: 中国科学通报：英文版

DOI: 10.1016/j.scib.2018.07.010

Authors: Zongmao Gao, Haoyuan Sun, Shanshan Qin, Xiaojing Yang, Chao Tang

Institutions: Peking University, Center for Life Sciences

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,880