Similar changes in neuropsychological functioning in english and spanish speaking HIV patients
Year: 2018
Type: article
Abstract: OBJECTIVE: Primary language has been reported to influence the results of neuropsychological (NP) testing. We sought to determine whether being a primary Spanish versus English speaker affects changes in neuropsychological evaluations in persons living with HIV. METHOD: Data from 209 (188 English speakers and 21 Spanish speakers) ART-naïve HIV-infected adults were extracted from ACTG A5303, a 48-week randomized clinical trial of two HIV treatment regimens. Participants' mean (standard deviation) age and years of education were 35.1 (10.7) and 14.3 (2.7) years respectively. Changes from baseline to week 48 of antiretroviral therapy (ART) in individual, total, and domain z-scores for NP tests and Global Deficit Scores (GDS) were compared between the primary languages using linear regression models, adjusted for baseline scores and years of education. RESULTS: Baseline demographic characteristics were comparable except Spanish speakers had less years of education than the English speakers (p < 0.001). Although differences in some NP measures and domains were detected at baseline, the adjusted changes in individual, total and domain NPz-scores from baseline to 48 weeks of ART were not significantly different between the two primary language groups. The 48-week changes in GDS were also similar. CONCLUSION: Changes in NP during ART were similar between English and Spanish speaking HIV-infected individuals for all NP measures. This suggests that studies of longitudinal changes in NP can pool participants across these languages.
Source: Brain and Behavior
DOI: 10.1002/brb3.1083
Authors: Onoja Akpa, Sachiko Miyahara, Babafemi Taiwo, Scott Evans, Baiba Berzins, Kevin Robertson
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,630
Funders: ACT Government, National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Dental and Craniofacial Research, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1032411263, G119332616, G1300708009, G1638502918, G174905615, G1819583291, Emory- Duke- Orlando- CDC (EmDOC) Clinical Trials Unit , G196810821, G2000225580, G2044651200, G2050726508, G2097247185, G2127051194, G2501702145, G3028964287, G3525517067, G374818150, G3810609436, G3873853564, G4354241396, G4553935269, G45629147, Miami HIV/AIDS Clinical Therapeutic and Vaccine Trial Unit, Case Clinical Trials Unit, Integrated University of Puerto Rico Clinical Trials Unit, G5408840199, The University of Rochester Clinical and Translational Science Institute, G5683069376, Institute for Clinical and Translational Research, G650174051, G661928818, North Carolina Translational and Clinical Science Institute (NC TraCS), Center for AIDS Research, Vanderbilt HIV Clinical Trials Unit, G690901646, The University of Rochester's Clinical and Translational Science Institute, Partners Healthcare Systems/Harvard Medical School/Boston Medical Center AIDS CTU, G7628721337, G7719837979, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Harvard/Boston/Providence Clinical Trials Unit (Harvard/B/P CTU), G857487509, Institute of Human Virology Clinical Trials Unit, G9000005716, G9000008330, G9000016284, G9000016497, G9000020237, G9000029981, G9000036922, G9000039438, G9000040595, G9000060926, G9000065939, G9000072212, G9000086287, G9000089892, G9000090785, G9000101693, G9000121661, G9000153861, G9000156378, G9000176126, G9000176289, G9000178147, G9000181071, G9000183894, G9000230774, G9000276314, G9000292181, G9000334266, Center for AIDS Research at Emory University, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), Columbia Collaborative HIV/AIDS Clinical Trials Unit, University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit
OpenAlex ID: W2883770619