Year: 2018
Type: article
Abstract: Brain damage can occasionally result in paradoxical functional benefit, which could help identify therapeutic targets for neuromodulation. However, these beneficial lesions are rare and lesions in multiple different brain locations can improve the same symptom. Using a technique called lesion network mapping, we show that heterogeneous lesion locations resulting in tremor relief are all connected to common nodes in the cerebellum and thalamus, the latter of which is a proven deep brain stimulation target for tremor. These results suggest that lesion network mapping can identify the common substrate underlying therapeutic lesions and effective therapeutic targets. Ann Neurol 2018;83:153-157.
Source: Annals of Neurology
DOI: 10.1002/ana.25285
Institutions: Beth Israel Deaconess Medical Center, Harvard University, University of Turku, Turku University Hospital, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Berenson Allen Center for Noninvasive Brain Stimulation, Charité – Universitätsmedizin Berlin, University of Würzburg, Universitätsklinikum Würzburg
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Dystonia Medical Research Foundation, Nancy Lurie Marks Family Foundation, Suomen Lääketieteen Säätiö, Deutsche Forschungsgemeinschaft, Academy of Finland, Orionin Tutkimussäätiö, Stiftung Charité, Thiemann Stiftung, Berlin Institute of Health, National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G1010926983, Use of Resting-State Networks to Predict the Ideal Site for Brain Stimulation, G1715922134, MRI-GENetics Interface Exploration_MRI-GENIE_Study, Statins augment small vessel function and improve stroke outcomes, G393103480, G599412843, Genetic variation in white matter hyperintensity and risk of ischemic stroke, Specialized Programs of Translational Research in Acute Stroke at the Partners, Center for Functional Imaging Technologies, A Storage Area Network for Structural and Functional Image Analysis, Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptoms, Silicon Graphics Prism Extreme 128P/1TB, Quantitative MRI-based metrics for multi-center stroke treatment assessment
OpenAlex ID: W2884001736