Chemistry for Positron Emission Tomography: Recent Advances in 11 C‐, 18 F‐, 13 N‐, and 15 O‐Labeling Reactions
Year: 2018
Type: review
Abstract: Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron‐emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on 11 C, 18 F, 13 N, and 15 O.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1201684657, PET ligand development for mGlu2 based on negative allosteric modulators, In vivo Probe for ionotropic glutamate signaling system: AMPA receptors, G3687771071, Novel PET Tracers for Imaging Monoacylglycerol Lipase in Endocannabinoid Signaling, New PET tracers for neuroimaging of FAAH in endocannabinoid signaling, G576783429, G6946693079, G7313658378, G7777734671, Neuro-PET Radiotracer Discovery for Imaging Glycogen Synthase Kinase-3, Novel PET Tracers for Imaging Monoacylglycerol Lipase in Endocannabinoid Signaling
OpenAlex ID: W2884017587