Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium
Year: 2018
Type: article
Abstract: Background: Antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG) proteins, especially pilus protein Gallo2178, have been consistently associated with colorectal cancer risk. Previous case–control studies and prospective studies with up to 8 years of follow-up, however, were unable to decipher the temporality of antibody responses to SGG in the context of the long-term multistep development of colorectal cancer. In this study, we analyzed a large U.S. colorectal cancer cohort consortium with follow-up beyond 10 years for antibody responses to SGG. Methods: We applied multiplex serology to measure antibody responses to 9 SGG proteins in participants of 10 prospective U.S. cohorts (CLUE, CPSII, HPFS, MEC, NHS, NYUWHS, PHS, PLCO, SCCS, and WHI) including 4,063 incident colorectal cancer cases and 4,063 matched controls. Conditional logistic regression was used to assess whether antibody responses to SGG were associated with colorectal cancer risk, overall and by time between blood draw and diagnosis. Results: Colorectal cancer risk was increased among those with antibody responses to Gallo2178, albeit not statistically significant [OR, 1.23; 95% confidence interval (CI), 0.99–1.52]. This association was stronger for cases diagnosed <10 years after blood draw (OR, 1.40; 95% CI, 1.09–1.79), but was not found among cases diagnosed ≥10 years after blood draw (OR, 0.79; 95% CI, 0.50–1.24). Conclusions: In a large cohort consortium, we reproduced the association of antibody responses to SGG Gallo2178 with colorectal cancer risk for individuals diagnosed within 10 years after blood draw. Impact: This timing-specific finding suggests that antibody responses to SGG are associated with increased colorectal cancer risk only after tumorigenesis has begun. Cancer Epidemiol Biomarkers Prev; 27(10); 1186–94. ©2018 AACR.
Authors: Julia Butt, William J. Blot, Lauren R. Teras, Kala Visvanathan, Loïc Le Marchand, Christopher A. Haiman, Yu Chen, Ying Bao, Howard D. Sesso, Sylvia Wassertheil-Smoller, Gloria Y. Ho, Lesley F. Tinker, Richard M. Peek, John D. Potter, Timothy L. Cover, Laura H. Hendrix, Li-Ching Huang, Tim Waterboer, Michael Pawlita, Meira Epplein
Institutions: Duke University, German Cancer Research Center, Heidelberg University, Duke Cancer Institute, Vanderbilt University Medical Center, American Cancer Society, Johns Hopkins University, University of Hawaii Cancer Center, University of Southern California, USC Norris Comprehensive Cancer Center, New York University, Brigham and Women's Hospital, Albert Einstein College of Medicine, Northwell Health, Feinstein Institute for Medical Research, Hofstra University, Fred Hutch Cancer Center, Vanderbilt University, VA Tennessee Valley Healthcare System
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, U.S. Department of Veterans Affairs, Presbyterian Historical Society, National Institutes of Health, Medical Engineering Centre, King’s College London, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1046522931, G1160275816, Structure and function of Helicobacter pylori VacA, G1747658766, G1851278524, G2069482854, G2214254730, Helicobacter Pylori and Gastrointestinal Biology, G3062349281, G3295293369, G3643850837, Dietary and Hormonal Determinants of Cancer in Women, G400951311, G4450071017, G4811508110, G4826281220, Physicians' Health Study II: Prevention Trial of Vitamins, G6445545215, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G6883568701, G7085675193, G7332203415, Cancer Epidemiology Cohort in Male Health Professionals, G8554986239, G8606882599, Molecular and Cellular Basis for Digestive Diseases, Type IV Protein Secretion in Helicobacter pylori, H. pylori-induced Inflammation and Gastric Cancer, Southern Community Cohort Study
OpenAlex ID: W2884059407