Year: 2018
Type: article
Abstract: A key concept in cancer genomics research is the idea that we can apply lessons learned from evolutionary biology to the study of tumorigenesis. If we consider the host as a challenging environment or niche, and the tumor as a sort of pseudospecies that thrives or dies out on the strength of individual transformed cells’ success within this environment, we can leverage evolutionary models to understand the importance of mutational events that contribute to tumor growth. This has aided in the identification of driver mutations that appear in cancer genomes at higher frequency than could reasonably be expected by chance.
Author: Mark R. Frey
Institution: Children's Hospital of Los Angeles
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,430
OpenAlex ID: W2884188680