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Cover Feature: Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds (ChemMedChem 14/2018)

Year: 2018

Type: article

Abstract: The Cover Feature shows how a single purine derivative inhibits the replication of multiple mosquito-borne flaviviruses by targeting a conserved allosteric pocket on NS5 polymerase, which is needed to bind NS3 helicase/protease and generate the functional replication complex. These inexpensive non-nucleoside broad-spectrum antivirals inhibit the replication of Zika virus and all serotypes of dengue virus (DENV 1–4) in infected cells at low micromolar concentration, with no adverse effect on a panel of selected host kinases. More information can be found in the Communication by Marco Radi et al. on page 1371 in Issue 14, 2018 (DOI: 10.1002/cmdc.201800178).

Source: ChemMedChem

DOI: 10.1002/cmdc.201800443

Authors: Suzanne J. F. Kaptein, Paolo Vincetti, Emmanuele Crespan, Jorge I. Armijos Rivera, Gabriele Costantino, Giovanni Maga, Johan Neyts, Marco Radi

Institutions: Rega Institute for Medical Research, KU Leuven, University of Parma, Istituto di Genetica Molecolare, National Research Council

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2884384850

FWCI:

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