Work

A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis

Year: 2018

Type: review

Abstract: is a leading cause of diarrhea globally. Largely an infection of impoverished communities in developing countries, amebiasis has emerged as an important infection among returning travelers, immigrants, and men who have sex with men residing in developed countries. Severe cases can be associated with high case fatality. Polymerase chain reaction-based diagnosis is increasingly available but remains underutilized. Nitroimidazoles are currently recommended for treatment, but new drug development to treat parasitic agents is a high priority. Amebiasis should be considered before corticosteroid therapy to decrease complications. There is no effective vaccine, so prevention focuses on sanitation and access to clean water. Further understanding of parasite biology and pathogenesis will advance future targeted therapeutic and preventative strategies.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofy161

Authors: Debbie-Ann T Shirley, Laura Farr, Koji Watanabe, Shannon Moonah

Institutions: University of Virginia, National Center for Global Health and Medicine

Language: English

Topic: Amoebic Infections and Treatments

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053