Work

Isolation and Characterization of Clinical Triazole Resistance Aspergillus fumigatus in Iran.

Year: 2018

Type: article

Abstract: BACKGROUND: isolates obtained from patients in Iran during 2010 to 2014. METHODS: isolates obtained from patients with underlying disease including transplantation, granulocytopenia, chronic liver disease, chronic obstructive pulmonary disease (COPD) and allergic bronchopulmonary aspergillosis (ABPA). Samples were collected between Jan 2009 and Nov 2014 from five provinces of Iran (Tehran, Shiraz, Isfahan, Khorasan razavi and East Azerbaijan). Antifungal susceptibility test was determined according to EUCAST reference method for itraconazole (ITC), voriconazole (VRC) and posaconazole (POS). All isolates were confirmed by amplification of the partial tubulin gene. RESULTS: isolates tested, six isolates (3.5%) had high MIC values of ITC (>16 mg/L) and VRC (≥4 mg/L). All six isolates showed a multi-resistant phenotype with high MICs of ITC and VRC. CONCLUSION: and international surveillance is warranted.

Source: Europe PMC (PubMed Central)

Authors: Faezezeh Mohammadi, Seyed Jamal Hashemi, Seyed Mojtaba Seyedmousavi, Dorna Akbarzade

Institutions: Qazvin University of Medical Sciences, Tehran University of Medical Sciences, Radboud University Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2884568705

FWCI: 0.961

Cites: 36

Cited by: 13

Related to: 10