Work

Metal‐Free Chlorothiolation of Alkenes Using HCl and Sulfoxides

Year: 2018

Type: article

Abstract: We report a novel method for the chlorothiolation of alkenes using HCl and sulfoxides to achieve the 1,2-difunctionalization of unactivated alkenes. The combination of our new HCl reagent (HCl/DMPU) with sulfoxides forms a unique chlorothiolation system. Both terminal and internal alkenes are suitable substrates. This method works at gram scale and is applicable in further synthetic elaborations.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201800973

Authors: Rene Ebule, Gerald B. Hammond, Bo Xu

Institutions: University of Louisville, Donghua University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of General Medical Sciences

Awards: G4645608422, Nucleophilic halogenation reagents