Work

Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data

Year: 2018

Type: article

Abstract: In this paper, we study a central problem in multimodal neuroimaging analysis, i.e., identification of significantly correlated brain regions between multiple imaging modalities. We propose a spatially varying correlation model and the associated inference procedure, which improves substantially over the common alternative solutions of voxel-wise and region-wise analysis. Compared with voxel-wise analysis, our method aggregates voxels with similar correlations into regions, takes into account spatial continuity of correlations at nearby voxels, and enjoys a much higher detection power. Compared with region-wise analysis, our method does not rely on any pre-specified brain region map, but instead finds homogenous correlation regions adaptively given the data. We applied our method to a multimodal positron emission tomography study, and found brain regions with significant correlation between tau and glucose metabolism that voxel-wise or region-wise analysis failed to identify. Our findings conform and lend additional support to prior hypotheses about how the two pathological proteins of Alzheimer's disease, tau and amyloid, interact with glucose metabolism in the aging human brain.

Source: IEEE Transactions on Medical Imaging

DOI: 10.1109/tmi.2018.2857221

Authors: Lexin Li, Jian Kang, Samuel N. Lockhart, Jenna Adams, William J. Jagust

Institutions: University of California, Berkeley, University of Michigan, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green