Year: 2018
Type: article
Study design: Observational Study
Abstract: Platelet Count and Mean Platelet Volume in Psoriasis PatientsP latelets are known to play an important role in inflam- mation and inflammatory diseases.[1] MPV (mean platelet volume) is accepted as a marker in platelet activation.[2] Psoriasis is an immune-mediated chronic systemic disease.The relation of platelet activation with the pathophysiology of psoriasis has also been described.[3] Activated platelets are thought to exert this effect by enhancing the migration of leukocytes into the skin and increasing cytokine release.In addition, the use of MPV has been suggested as a predictor [4] for MPV, cardiovascular risk, and marker [5] for ankylosing spondylitis and rheumatoid arthritis.In recent studies, the relationship between MPV, platelet count and other hematological parameters and psoriasis has been investigated, but different results have been found.In this study, we compared the platelet count and MPV levels of psoriasis patients with the healthy control group and examined whether these values correlated with PASI (Psoriasis Area Severity İndex). MethodsThis case-control study included 28 psoriatic patients and age and gender-matched 30 healthy control subjects.Non-Objectives: Psoriasis is a chronic inflammatory, immune-mediated disease, and platelets have an important role in the pathomechanisms of psoriasis.Recent studies showed that MPV (mean platelet volume) could be used as a marker of platelet activation.In this study, we aimed to investigate the MPV level and platelet count in psoriasis patients and its association with disease severity.Methods: We designed a case-control study with 28 psoriasis patients and age and sex-matched 30 healthy controls.Haematologic parameters and sedimentation rates compared between groups.These parameters also correlated with PASI (Psoriasis Area and Severity Index) score.Results: MPV and platelet count were significantly higher in patients with psoriasis than controls (p=0.012,p=0.015).Also, platelet count was showed positive correlation with PASI scores (r=0.424,p=0.025).The sedimentation rate was not statistically different between groups.Conclusion: There are many conflicting results about the correlation of haematologic parameters and psoriasis.We found that MPV and platelet counts higher in the psoriasis group, which suggests that platelets play an important role in the pathomechanism of psoriasis and may be helpful in assessing treatment outcomes.
Author: Ezgi Özkur
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2884828926