Year: 2018
Type: article
Abstract: The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds.On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membrane of eukaryotic cells, including endo-and exocytosis, phagocytosis and filopodia formation.On the other hand, a multitude of intracellular processes at the level of organelles rely on generation, modulation, and maintenance of membrane curvature to maintain the organelle shape and functionality.The contribution of biophysicists and biologists is essential for shedding light on the mechanistic understanding and quantification of these processes.Given the vast complexity of phenomena and mechanisms involved in the coupling between membrane shape and function, it is not always clear in what direction to advance to eventually arrive at an exhaustive understanding of this important research area.The 2018 Biomembrane Curvature and Remodeling Roadmap of Journal of Physics D: Applied Physics addresses this need for clarity and is intended to provide guidance both for students who have just entered the field as well as established scientists who would like to improve their orientation within this fascinating area.
Authors: Patricia Bassereau, Rui Jin, Tobias Baumgart, Markus Deserno, Rumiana Dimova, Vadim A Frolov, Pavel V Bashkirov, Helmut Grubmüller, Reinhard Jahn, H Jelger Risselada, Ludger Johannes, Michael M Kozlov, Reinhard Lipowsky, Thomas J Pucadyil, Wade F Zeno, Jeanne C Stachowiak, Dimitrios Stamou, Artù Breuer, Line Lauritsen, Camille Simon, Cécile Sykes, Gregory A Voth, Thomas R Weikl
Institutions: Centre National de la Recherche Scientifique, Université Paris Sciences et Lettres, Sorbonne Université, Physique des Cellules et Cancers, Institut Curie, University of Pennsylvania, Carnegie Mellon University, Max Planck Institute of Colloids and Interfaces, Ikerbasque, University of the Basque Country, Instituto Biofisika, Russian Academy of Sciences, Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin, Max Planck Institute for Biophysical Chemistry, University of Göttingen, Inserm, Chimie et Biologie de la Cellule, Tel Aviv University, Indian Institute of Science Education and Research Pune, The University of Texas at Austin, University of Copenhagen, University of Chicago
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,325
Funders: National Science Foundation, Wellcome Trust, Innovationsfonden, European Commission, Department of Biotechnology, Ministry of Science and Technology, India, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, Bundesministerium für Bildung und Forschung, Fondation pour la Recherche Médicale, Ministerio de Economía y Competitividad, Lundbeckfonden, Israel Science Foundation, Max-Planck-Gesellschaft, Novo Nordisk, Vetenskapsrådet, Centre National de la Recherche Scientifique, Russian Science Foundation, The Wellcome Trust DBT India Alliance, Université de Recherche Paris Sciences et Lettres, Novo Nordisk Fonden, H. Lundbeck A/S, Labex CelTisPhyBio, National Institutes of Health, National Institute of General Medical Sciences
Awards: Membrane shape transition control in cellular membrane trafficking phenomena, G2152283813, G256400847, Paris Sciences et Lettres, G4190806336, In vivo proof of concept of molecules against hemolytic uremic syndrome, G471331628, G4950536974, Des cellules aux tissus: au croisement de la Physique et de la Biologie, Data Assimilation and Lattice LIght SHeet imaging for endocytosis/exocytosis pathway modeling in the whole cell, Deciphering parasite-specific factors involved in retrograde trafficking and virulence of Toxoplasma gondii, G6358499467, Mechanical connection between the actin cytoskeleton and the nucleus, G7240651115, G7372558840, Predicting emergent continuum-elastic properties of lipid membranes from molecular-level simulations via consistent and model-free scale bridging, G782245399, G8122203363, G8976023288
OpenAlex ID: W2884865116