Work

Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis

Year: 2018

Type: article

Abstract: Key Points Wt1 heterozygous loss enhanced stem cell self-renewal in an age-dependent manner. Wt1-haploinsufficient leukemias require additional events to promote hematopoietic transformation.

Source: Blood

DOI: 10.1182/blood-2018-03-837468

Authors: Elodie Pronier, Robert L. Bowman, Jihae Ahn, Jacob Glass, Cyriac Kandoth, Tiffany R. Merlinsky, Justin T. Whitfield, Benjamin H. Durham, Antoine Gruet, Amritha Varshini Hanasoge Somasundara, Raajit Rampal, Ari Melnick, Richard P. Koche, Barry S. Taylor, Ross L. Levine

Institutions: Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: European Hematology Association, National Institutes of Health, National Cancer Institute

Awards: G8754034597, G9000079197, Cancer Center Support Grant, Synergistic role of signaling and epigenetics in leukemic transformation

OpenAlex ID: W2885031969

FWCI: 4.407

Cites: 50

Cited by: 52

Related to: 10