Year: 2021
Type: article
Study design: Observational Study
Abstract: Tardive dyskinesia (TD) is a severe condition characterized by repetitive involuntary movement of orofacial regions and extremities. Patients treated with antipsychotics typically present with TD symptomatology. Here, we conducted the largest GWAS of TD to date, by meta-analyzing samples of East-Asian, European, and African American ancestry, followed by analyses of biological pathways and polygenic risk with related phenotypes. We identified a novel locus and three suggestive loci, implicating immune-related pathways. Through integrating trans-ethnic fine mapping, we identified putative credible causal variants for three of the loci. Post-hoc analysis revealed that SNPs harbored in TNFRSF1B and CALCOCO1 independently conferred three-fold increase in TD risk, beyond clinical risk factors like Age of onset and Duration of illness to schizophrenia. Further work is necessary to replicate loci that are reported in the study and evaluate the polygenic architecture underlying TD.
Source: Translational Psychiatry
Institutions: Institute of Mental Health, Feinstein Institute for Medical Research, Zucker Hillside Hospital, Centre for Addiction and Mental Health, University of Toronto, Genome Institute of Singapore, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, University of Delhi, Nagoya University, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, National University of Singapore, Nanyang Technological University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,380
Awards: G1121004391, G2148141080, G2743376274, G3133665439, G3303670509, G3652973337, G445903376, Development of a device for estimating the severity of depression using a voice recognition system based on deep learning and artificial intelligence techniques, G4718590172, G5253811515, G6433742145, G7040666340, G7467997106, G7483578005, CLINICAL ANTIPSYCHOTIC TRIALS OF INTERVENTION EFFECTIVES, G909501650
OpenAlex ID: W3168778565