Work

Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

Year: 2018

Type: article

Abstract: degradation, and anti-thrombogenicity of the resultant PU-DPA polymers can be tuned by altering the incorporated DPA amount. The surface and bulk hydrophilicity of the polyurethanes decreased with increasing hydrophobic DPA amount. All PU-DPA polymers exhibited strong mechanical properties and good elasticity. The degradation rates of the PU-DPAs decreased with increasing DPA content in both PBS and lipase/PBS solutions. Covalently incorporating DPA into the polyurethane significantly reduced the platelet adhesion and activation compared to the polyurethane without DPA, and also can achieve sustained anti-thrombogenicity. The PU-DPA films also supported the growth of human umbilical vein endothelial cells. The attractive mechanical properties, blood compatibility, and cell compatibility of this anti-thrombogenic biodegradable polyurethane indicate that it has a great potential to be utilized for blood-contacting devices, and cardiovascular tissue repair and regeneration.

Source: Journal of Materials Chemistry B

DOI: 10.1039/c8tb01582a

Authors: Cancan Xu, Aneetta E. Kuriakose, Danh Truong, Primana Punnakitikashem, Kytai T. Nguyen, Yi Hong

Institutions: The University of Texas at Arlington, The University of Texas Southwestern Medical Center

Language: English

Topic: Polymer Surface Interaction Studies

Subfield: Surfaces, Coatings and Films

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Child Health and Human Development, Division of Materials Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development