Work

Activity of Aromathecins against African Trypanosomes

Year: 2018

Type: article

Abstract: poisoning activity against the phylogenetically unique topoisomerase in these parasites, and a representative compound intercalated into DNA with micromolar affinity. DNA intercalation and topoisomerase poisoning may contribute to the antitrypanosomal activity of aromathecins.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00786-18

Authors: Nathaniel P. Nenortas, Maris A. Cinelli, Andrew E. Morrell, Mark Cushman, Theresa A. Shapiro

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Purdue University West Lafayette, Purdue University Institute for Cancer Research

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases